Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 mimicking Kawasaki disease (Kawa-COVID-19): a multicentre cohort.
Identifieur interne : 000991 ( Main/Exploration ); précédent : 000990; suivant : 000992Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 mimicking Kawasaki disease (Kawa-COVID-19): a multicentre cohort.
Auteurs : Marie Pouletty [France] ; Charlotte Borocco [France] ; Naim Ouldali [France] ; Marion Caseris [France] ; Romain Basmaci [France] ; Noémie Lachaume [France] ; Philippe Bensaid [France] ; Samia Pichard [France] ; Hanane Kouider [France] ; Guillaume Morelle [France] ; Irina Craiu [France] ; Corinne Pondarre [France] ; Anna Deho [France] ; Arielle Maroni [France] ; Mehdi Oualha [France] ; Zahir Amoura [France] ; Julien Haroche [France] ; Juliette Chommeloux [France] ; Fanny Bajolle [France] ; Constance Beyler [France] ; Stéphane Bonacorsi [France] ; Guislaine Carcelain [France] ; Isabelle Koné-Paut [France] ; Brigitte Bader-Meunier [France] ; Albert Faye [France] ; Ulrich Meinzer [France] ; Caroline Galeotti [France] ; Isabelle Melki [France]Source :
- Annals of the rheumatic diseases [ 1468-2060 ] ; 2020.
Descripteurs français
- KwdFr :
- Adolescent (MeSH), Betacoronavirus (MeSH), Diagnostic différentiel (MeSH), Enfant (MeSH), Enfant d'âge préscolaire (MeSH), Femelle (MeSH), Humains (MeSH), Infections à coronavirus (diagnostic), Infections à coronavirus (virologie), Infections à coronavirus (épidémiologie), Maladie de Kawasaki (diagnostic), Maladie de Kawasaki (virologie), Mâle (MeSH), Pandémies (MeSH), Paris (épidémiologie), Pneumopathie virale (diagnostic), Pneumopathie virale (virologie), Pneumopathie virale (épidémiologie), Syndrome de réponse inflammatoire généralisée (diagnostic), Syndrome de réponse inflammatoire généralisée (virologie), Syndrome de réponse inflammatoire généralisée (épidémiologie), Études de cohortes (MeSH).
- MESH :
- diagnostic : Infections à coronavirus, Maladie de Kawasaki, Pneumopathie virale, Syndrome de réponse inflammatoire généralisée.
- virologie : Infections à coronavirus, Maladie de Kawasaki, Pneumopathie virale, Syndrome de réponse inflammatoire généralisée.
- épidémiologie : Infections à coronavirus, Paris, Pneumopathie virale, Syndrome de réponse inflammatoire généralisée.
- Adolescent, Betacoronavirus, Diagnostic différentiel, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Mâle, Pandémies, Études de cohortes.
English descriptors
- KwdEn :
- Adolescent (MeSH), Betacoronavirus (MeSH), Child (MeSH), Child, Preschool (MeSH), Cohort Studies (MeSH), Coronavirus Infections (diagnosis), Coronavirus Infections (epidemiology), Coronavirus Infections (virology), Diagnosis, Differential (MeSH), Female (MeSH), Humans (MeSH), Male (MeSH), Mucocutaneous Lymph Node Syndrome (diagnosis), Mucocutaneous Lymph Node Syndrome (virology), Pandemics (MeSH), Paris (epidemiology), Pneumonia, Viral (diagnosis), Pneumonia, Viral (epidemiology), Pneumonia, Viral (virology), Systemic Inflammatory Response Syndrome (diagnosis), Systemic Inflammatory Response Syndrome (epidemiology), Systemic Inflammatory Response Syndrome (virology).
- MESH :
- geographic , epidemiology : Paris.
- diagnosis : Coronavirus Infections, Mucocutaneous Lymph Node Syndrome, Pneumonia, Viral, Systemic Inflammatory Response Syndrome.
- epidemiology : Coronavirus Infections, Pneumonia, Viral, Systemic Inflammatory Response Syndrome.
- virology : Coronavirus Infections, Mucocutaneous Lymph Node Syndrome, Pneumonia, Viral, Systemic Inflammatory Response Syndrome.
- Adolescent, Betacoronavirus, Child, Child, Preschool, Cohort Studies, Diagnosis, Differential, Female, Humans, Male, Pandemics.
Abstract
BACKGROUND
Current data suggest that COVID-19 is less frequent in children, with a milder course. However, over the past weeks, an increase in the number of children presenting to hospitals in the greater Paris region with a phenotype resembling Kawasaki disease (KD) has led to an alert by the French national health authorities.
METHODS
Multicentre compilation of patients with KD in Paris region since April 2020, associated with the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ('Kawa-COVID-19'). A historical cohort of 'classical' KD served as a comparator.
RESULTS
Sixteen patients were included (sex ratio=1, median age 10 years IQR (4·7 to 12.5)). SARS-CoV-2 was detected in 12 cases (69%), while a further three cases had documented recent contact with a quantitative PCR-positive individual (19%). Cardiac involvement included myocarditis in 44% (n=7). Factors prognostic for the development of severe disease (ie, requiring intensive care, n=7) were age over 5 years and ferritinaemia >1400 µg/L. Only five patients (31%) were successfully treated with a single intravenous immunoglobulin (IVIg) infusion, while 10 patients (62%) required a second line of treatment. The Kawa-COVID-19 cohort differed from a comparator group of 'classical' KD by older age at onset 10 vs 2 years (p<0.0001), lower platelet count (188 vs 383 G/L (p<0.0001)), a higher rate of myocarditis 7/16 vs 3/220 (p=0.0001) and resistance to first IVIg treatment 10/16 vs 45/220 (p=0.004).
CONCLUSION
Kawa-COVID-19 likely represents a new systemic inflammatory syndrome temporally associated with SARS-CoV-2 infection in children. Further prospective international studies are necessary to confirm these findings and better understand the pathophysiology of Kawa-COVID-19.
DOI: 10.1136/annrheumdis-2020-217960
PubMed: 32527868
PubMed Central: PMC7299653
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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General Paediatrics and Paediatric Emergency, Louis-Mourier Hospital, AP-HP, Colombes</wicri:regionArea><wicri:noRegion>Colombes</wicri:noRegion><wicri:noRegion>Colombes</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:affiliation>Infection-Antimicrobials-Modelling-Evolution IAME, INSERM, UMR-1137, Université de Paris, 75018, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Infection-Antimicrobials-Modelling-Evolution IAME, INSERM, UMR-1137, Université de Paris, 75018, Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bensaid, Philippe" sort="Bensaid, Philippe" uniqKey="Bensaid P" first="Philippe" last="Bensaid">Philippe Bensaid</name><affiliation wicri:level="3"><nlm:affiliation>Department of General Paediatrics, Victor Dupouy Hospital, Argenteuil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of General Paediatrics, Victor Dupouy Hospital, Argenteuil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Argenteuil (Val-d'Oise)</settlement></placeName></affiliation></author><author><name sortKey="Pichard, Samia" sort="Pichard, Samia" uniqKey="Pichard S" first="Samia" last="Pichard">Samia Pichard</name><affiliation wicri:level="3"><nlm:affiliation>Department of General Paediatrics, Victor Dupouy Hospital, Argenteuil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of General Paediatrics, Victor Dupouy Hospital, Argenteuil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Argenteuil (Val-d'Oise)</settlement></placeName></affiliation></author><author><name sortKey="Kouider, Hanane" sort="Kouider, Hanane" uniqKey="Kouider H" first="Hanane" last="Kouider">Hanane Kouider</name><affiliation wicri:level="3"><nlm:affiliation>Department of General Paediatrics, René Dubos, Pontoise Hospital, Pontoise, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of General Paediatrics, René Dubos, Pontoise Hospital, Pontoise</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Pontoise</settlement></placeName></affiliation></author><author><name sortKey="Morelle, Guillaume" sort="Morelle, Guillaume" uniqKey="Morelle G" first="Guillaume" last="Morelle">Guillaume Morelle</name><affiliation wicri:level="1"><nlm:affiliation>Department of General Paediatrics, Hôpital Bicêtre, AP-HP, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of General Paediatrics, Hôpital Bicêtre, AP-HP, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Craiu, Irina" sort="Craiu, Irina" uniqKey="Craiu I" first="Irina" last="Craiu">Irina Craiu</name><affiliation wicri:level="1"><nlm:affiliation>Paediatric emergency Department, Hôpital Bicêtre, AP-HP, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Paediatric emergency Department, Hôpital Bicêtre, AP-HP, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Pondarre, Corinne" sort="Pondarre, Corinne" uniqKey="Pondarre C" first="Corinne" last="Pondarre">Corinne Pondarre</name><affiliation wicri:level="3"><nlm:affiliation>Sickle cell disease referal center, INSERM U955, Centre hospitalier Intercommunal de Créteil, Paris XII University, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Sickle cell disease referal center, INSERM U955, Centre hospitalier Intercommunal de Créteil, Paris XII University, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Deho, Anna" sort="Deho, Anna" uniqKey="Deho A" first="Anna" last="Deho">Anna Deho</name><affiliation wicri:level="3"><nlm:affiliation>Paediatric Intensive Care Unit, Robert Debré University Hospital, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Paediatric Intensive Care Unit, Robert Debré University Hospital, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Maroni, Arielle" sort="Maroni, Arielle" uniqKey="Maroni A" first="Arielle" last="Maroni">Arielle Maroni</name><affiliation wicri:level="3"><nlm:affiliation>Paediatric Intensive Care Unit, Robert Debré University Hospital, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Paediatric Intensive Care Unit, Robert Debré University Hospital, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Oualha, Mehdi" sort="Oualha, Mehdi" uniqKey="Oualha M" first="Mehdi" last="Oualha">Mehdi Oualha</name><affiliation wicri:level="3"><nlm:affiliation>Paediatric Intensive Care Unit, Necker-Enfants-Malades University Hospital, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Paediatric Intensive Care Unit, Necker-Enfants-Malades University Hospital, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Amoura, Zahir" sort="Amoura, Zahir" uniqKey="Amoura Z" first="Zahir" last="Amoura">Zahir Amoura</name><affiliation wicri:level="3"><nlm:affiliation>Inserm UMR-S 1135, Sorbonne Université, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm UMR-S 1135, Sorbonne Université, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Immunology and Infectious disease (CIMI-Paris), Pitié-Salpêtrière Hospital, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Immunology and Infectious disease (CIMI-Paris), Pitié-Salpêtrière Hospital, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Haroche, Julien" sort="Haroche, Julien" uniqKey="Haroche J" first="Julien" last="Haroche">Julien Haroche</name><affiliation wicri:level="3"><nlm:affiliation>Inserm UMR-S 1135, Sorbonne Université, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm UMR-S 1135, Sorbonne Université, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Immunology and Infectious disease (CIMI-Paris), Pitié-Salpêtrière Hospital, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Immunology and Infectious disease (CIMI-Paris), Pitié-Salpêtrière Hospital, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Chommeloux, Juliette" sort="Chommeloux, Juliette" uniqKey="Chommeloux J" first="Juliette" last="Chommeloux">Juliette Chommeloux</name><affiliation wicri:level="3"><nlm:affiliation>Medical Intensive Care Unit, Institut de Cardiologie, AP-HP, Sorbonne University, Pitié-Salpêtrière Hospital, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Medical Intensive Care Unit, Institut de Cardiologie, AP-HP, Sorbonne University, Pitié-Salpêtrière Hospital, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bajolle, Fanny" sort="Bajolle, Fanny" uniqKey="Bajolle F" first="Fanny" last="Bajolle">Fanny Bajolle</name><affiliation wicri:level="3"><nlm:affiliation>Cardiopaediatric Unit, M3-C, Necker-Enfants-Malades University Hospital, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Cardiopaediatric Unit, M3-C, Necker-Enfants-Malades University Hospital, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Beyler, Constance" sort="Beyler, Constance" uniqKey="Beyler C" first="Constance" last="Beyler">Constance Beyler</name><affiliation wicri:level="3"><nlm:affiliation>Cardiopaediatric Unit, Robert Debré University Hospital, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Cardiopaediatric Unit, Robert Debré University Hospital, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bonacorsi, Stephane" sort="Bonacorsi, Stephane" uniqKey="Bonacorsi S" first="Stéphane" last="Bonacorsi">Stéphane Bonacorsi</name><affiliation wicri:level="3"><nlm:affiliation>Department of Microbiology, Robert Debré University Hospital,AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Microbiology, Robert Debré University Hospital,AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Infection-Antimicrobials-Modelling-Evolution IAME, INSERM, UMR-1137, Université de Paris, 75018, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Infection-Antimicrobials-Modelling-Evolution IAME, INSERM, UMR-1137, Université de Paris, 75018, Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Carcelain, Guislaine" sort="Carcelain, Guislaine" uniqKey="Carcelain G" first="Guislaine" last="Carcelain">Guislaine Carcelain</name><affiliation wicri:level="3"><nlm:affiliation>Department of Immunology, Robert Debré University Hospital, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Immunology, Robert Debré University Hospital, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Kone Paut, Isabelle" sort="Kone Paut, Isabelle" uniqKey="Kone Paut I" first="Isabelle" last="Koné-Paut">Isabelle Koné-Paut</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatric Rheumatology Reference centre for Autoinflammatory diseases and amyloidosis (CEREMAIA), Hôpital Bicêtre, AP-HP, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Pediatric Rheumatology Reference centre for Autoinflammatory diseases and amyloidosis (CEREMAIA), Hôpital Bicêtre, AP-HP, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:affiliation>Université Paris Sud-Saclay, UVSQ, 94276 Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Sud-Saclay, UVSQ, 94276 Le Kremlin-Bicêtre</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Le Kremlin-Bicêtre</settlement></placeName></affiliation></author><author><name sortKey="Bader Meunier, Brigitte" sort="Bader Meunier, Brigitte" uniqKey="Bader Meunier B" first="Brigitte" last="Bader-Meunier">Brigitte Bader-Meunier</name><affiliation wicri:level="3"><nlm:affiliation>Paediatric Hematology-Immunology and Rheumatology Department, Reference centre for Rheumatic, AutoImmune and Systemic diseases in children (RAISE), Paris, France, Necker-Enfants-Malades University Hospital, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Paediatric Hematology-Immunology and Rheumatology Department, Reference centre for Rheumatic, AutoImmune and Systemic diseases in children (RAISE), Paris, France, Necker-Enfants-Malades University Hospital, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Laboratory of Immunogenetics of paediatric autoimmune diseases, INSERM UMR 1163, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratory of Immunogenetics of paediatric autoimmune diseases, INSERM UMR 1163, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Faye, Albert" sort="Faye, Albert" uniqKey="Faye A" first="Albert" last="Faye">Albert Faye</name><affiliation wicri:level="3"><nlm:affiliation>General Paediatrics, Department of Infectious Disease and Internal Medicine, Reference centre for Rheumatic, AutoImmune and Systemic diseases in children (RAISE), Paris, France, Robert Debré University Hospital, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>General Paediatrics, Department of Infectious Disease and Internal Medicine, Reference centre for Rheumatic, AutoImmune and Systemic diseases in children (RAISE), Paris, France, Robert Debré University Hospital, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Université de Paris, UFR de Médecine Paris Nord, 75010 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Paris, UFR de Médecine Paris Nord, 75010 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>INSERM UMR 1123, ECEVE, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR 1123, ECEVE, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Meinzer, Ulrich" sort="Meinzer, Ulrich" uniqKey="Meinzer U" first="Ulrich" last="Meinzer">Ulrich Meinzer</name><affiliation wicri:level="3"><nlm:affiliation>General Paediatrics, Department of Infectious Disease and Internal Medicine, Reference centre for Rheumatic, AutoImmune and Systemic diseases in children (RAISE), Paris, France, Robert Debré University Hospital, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>General Paediatrics, Department of Infectious Disease and Internal Medicine, Reference centre for Rheumatic, AutoImmune and Systemic diseases in children (RAISE), Paris, France, Robert Debré University Hospital, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Université de Paris, UFR de Médecine Paris Nord, 75010 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Paris, UFR de Médecine Paris Nord, 75010 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Center for Research on Inflammation, INSERM, UMR1149, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Center for Research on Inflammation, INSERM, UMR1149, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Biology and Genetics of Bacterial Cell Wall Unit, Pasteur Institute, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Biology and Genetics of Bacterial Cell Wall Unit, Pasteur Institute, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Galeotti, Caroline" sort="Galeotti, Caroline" uniqKey="Galeotti C" first="Caroline" last="Galeotti">Caroline Galeotti</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatric Rheumatology Reference centre for Autoinflammatory diseases and amyloidosis (CEREMAIA), Hôpital Bicêtre, AP-HP, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Pediatric Rheumatology Reference centre for Autoinflammatory diseases and amyloidosis (CEREMAIA), Hôpital Bicêtre, AP-HP, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Melki, Isabelle" sort="Melki, Isabelle" uniqKey="Melki I" first="Isabelle" last="Melki">Isabelle Melki</name><affiliation wicri:level="3"><nlm:affiliation>General Paediatrics, Department of Infectious Disease and Internal Medicine, Reference centre for Rheumatic, AutoImmune and Systemic diseases in children (RAISE), Paris, France, Robert Debré University Hospital, AP-HP, Paris, France isabelle.melki@aphp.fr.</nlm:affiliation><country wicri:rule="url">France</country><wicri:regionArea>General Paediatrics, Department of Infectious Disease and Internal Medicine, Reference centre for Rheumatic, AutoImmune and Systemic diseases in children (RAISE), Paris, France, Robert Debré University Hospital, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Paediatric Hematology-Immunology and Rheumatology Department, Reference centre for Rheumatic, AutoImmune and Systemic diseases in children (RAISE), Paris, France, Necker-Enfants-Malades University Hospital, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Paediatric Hematology-Immunology and Rheumatology Department, Reference centre for Rheumatic, AutoImmune and Systemic diseases in children (RAISE), Paris, France, Necker-Enfants-Malades University Hospital, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Laboratory of Neurogenetics and Neuroinflammation, Imagine Institute, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratory of Neurogenetics and Neuroinflammation, Imagine Institute, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32527868</idno><idno type="pmid">32527868</idno><idno type="doi">10.1136/annrheumdis-2020-217960</idno><idno type="pmc">PMC7299653</idno><idno type="wicri:Area/Main/Corpus">000E33</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000E33</idno><idno type="wicri:Area/Main/Curation">000E33</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000E33</idno><idno type="wicri:Area/Main/Exploration">000E33</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 mimicking Kawasaki disease (Kawa-COVID-19): a multicentre cohort.</title><author><name sortKey="Pouletty, Marie" sort="Pouletty, Marie" uniqKey="Pouletty M" first="Marie" last="Pouletty">Marie Pouletty</name><affiliation wicri:level="3"><nlm:affiliation>General Paediatrics, Department of Infectious Disease and Internal Medicine, Reference centre for Rheumatic, AutoImmune and Systemic diseases in children (RAISE), Paris, France, Robert Debré University Hospital, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>General Paediatrics, Department of Infectious Disease and Internal Medicine, Reference centre for Rheumatic, AutoImmune and Systemic diseases in children (RAISE), Paris, France, Robert Debré University Hospital, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Université de Paris, UFR de Médecine Paris Nord, 75010 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Paris, UFR de Médecine Paris Nord, 75010 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Borocco, Charlotte" sort="Borocco, Charlotte" uniqKey="Borocco C" first="Charlotte" last="Borocco">Charlotte Borocco</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatric Rheumatology Reference centre for Autoinflammatory diseases and amyloidosis (CEREMAIA), Hôpital Bicêtre, AP-HP, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Pediatric Rheumatology Reference centre for Autoinflammatory diseases and amyloidosis (CEREMAIA), Hôpital Bicêtre, AP-HP, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:affiliation>Université Paris Sud-Saclay, UVSQ, 94276 Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Sud-Saclay, UVSQ, 94276 Le Kremlin-Bicêtre</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Le Kremlin-Bicêtre</settlement></placeName></affiliation></author><author><name sortKey="Ouldali, Naim" sort="Ouldali, Naim" uniqKey="Ouldali N" first="Naim" last="Ouldali">Naim Ouldali</name><affiliation wicri:level="3"><nlm:affiliation>General Paediatrics, Department of Infectious Disease and Internal Medicine, Reference centre for Rheumatic, AutoImmune and Systemic diseases in children (RAISE), Paris, France, Robert Debré University Hospital, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>General Paediatrics, Department of Infectious Disease and Internal Medicine, Reference centre for Rheumatic, AutoImmune and Systemic diseases in children (RAISE), Paris, France, Robert Debré University Hospital, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>INSERM UMR 1123, ECEVE, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR 1123, ECEVE, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Caseris, Marion" sort="Caseris, Marion" uniqKey="Caseris M" first="Marion" last="Caseris">Marion Caseris</name><affiliation wicri:level="3"><nlm:affiliation>General Paediatrics, Department of Infectious Disease and Internal Medicine, Reference centre for Rheumatic, AutoImmune and Systemic diseases in children (RAISE), Paris, France, Robert Debré University Hospital, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>General Paediatrics, Department of Infectious Disease and Internal Medicine, Reference centre for Rheumatic, AutoImmune and Systemic diseases in children (RAISE), Paris, France, Robert Debré University Hospital, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Microbiology, Robert Debré University Hospital,AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Microbiology, Robert Debré University Hospital,AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Basmaci, Romain" sort="Basmaci, Romain" uniqKey="Basmaci R" first="Romain" last="Basmaci">Romain Basmaci</name><affiliation wicri:level="1"><nlm:affiliation>Departments of General Paediatrics and Paediatric Emergency, Louis-Mourier Hospital, AP-HP, Colombes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Departments of General Paediatrics and Paediatric Emergency, Louis-Mourier Hospital, AP-HP, Colombes</wicri:regionArea><wicri:noRegion>Colombes</wicri:noRegion><wicri:noRegion>Colombes</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:affiliation>Infection-Antimicrobials-Modelling-Evolution IAME, INSERM, UMR-1137, Université de Paris, 75018, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Infection-Antimicrobials-Modelling-Evolution IAME, INSERM, UMR-1137, Université de Paris, 75018, Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lachaume, Noemie" sort="Lachaume, Noemie" uniqKey="Lachaume N" first="Noémie" last="Lachaume">Noémie Lachaume</name><affiliation wicri:level="1"><nlm:affiliation>Departments of General Paediatrics and Paediatric Emergency, Louis-Mourier Hospital, AP-HP, Colombes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Departments of General Paediatrics and Paediatric Emergency, Louis-Mourier Hospital, AP-HP, Colombes</wicri:regionArea><wicri:noRegion>Colombes</wicri:noRegion><wicri:noRegion>Colombes</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:affiliation>Infection-Antimicrobials-Modelling-Evolution IAME, INSERM, UMR-1137, Université de Paris, 75018, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Infection-Antimicrobials-Modelling-Evolution IAME, INSERM, UMR-1137, Université de Paris, 75018, Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bensaid, Philippe" sort="Bensaid, Philippe" uniqKey="Bensaid P" first="Philippe" last="Bensaid">Philippe Bensaid</name><affiliation wicri:level="3"><nlm:affiliation>Department of General Paediatrics, Victor Dupouy Hospital, Argenteuil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of General Paediatrics, Victor Dupouy Hospital, Argenteuil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Argenteuil (Val-d'Oise)</settlement></placeName></affiliation></author><author><name sortKey="Pichard, Samia" sort="Pichard, Samia" uniqKey="Pichard S" first="Samia" last="Pichard">Samia Pichard</name><affiliation wicri:level="3"><nlm:affiliation>Department of General Paediatrics, Victor Dupouy Hospital, Argenteuil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of General Paediatrics, Victor Dupouy Hospital, Argenteuil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Argenteuil (Val-d'Oise)</settlement></placeName></affiliation></author><author><name sortKey="Kouider, Hanane" sort="Kouider, Hanane" uniqKey="Kouider H" first="Hanane" last="Kouider">Hanane Kouider</name><affiliation wicri:level="3"><nlm:affiliation>Department of General Paediatrics, René Dubos, Pontoise Hospital, Pontoise, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of General Paediatrics, René Dubos, Pontoise Hospital, Pontoise</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Pontoise</settlement></placeName></affiliation></author><author><name sortKey="Morelle, Guillaume" sort="Morelle, Guillaume" uniqKey="Morelle G" first="Guillaume" last="Morelle">Guillaume Morelle</name><affiliation wicri:level="1"><nlm:affiliation>Department of General Paediatrics, Hôpital Bicêtre, AP-HP, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of General Paediatrics, Hôpital Bicêtre, AP-HP, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Craiu, Irina" sort="Craiu, Irina" uniqKey="Craiu I" first="Irina" last="Craiu">Irina Craiu</name><affiliation wicri:level="1"><nlm:affiliation>Paediatric emergency Department, Hôpital Bicêtre, AP-HP, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Paediatric emergency Department, Hôpital Bicêtre, AP-HP, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Pondarre, Corinne" sort="Pondarre, Corinne" uniqKey="Pondarre C" first="Corinne" last="Pondarre">Corinne Pondarre</name><affiliation wicri:level="3"><nlm:affiliation>Sickle cell disease referal center, INSERM U955, Centre hospitalier Intercommunal de Créteil, Paris XII University, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Sickle cell disease referal center, INSERM U955, Centre hospitalier Intercommunal de Créteil, Paris XII University, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Deho, Anna" sort="Deho, Anna" uniqKey="Deho A" first="Anna" last="Deho">Anna Deho</name><affiliation wicri:level="3"><nlm:affiliation>Paediatric Intensive Care Unit, Robert Debré University Hospital, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Paediatric Intensive Care Unit, Robert Debré University Hospital, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Maroni, Arielle" sort="Maroni, Arielle" uniqKey="Maroni A" first="Arielle" last="Maroni">Arielle Maroni</name><affiliation wicri:level="3"><nlm:affiliation>Paediatric Intensive Care Unit, Robert Debré University Hospital, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Paediatric Intensive Care Unit, Robert Debré University Hospital, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Oualha, Mehdi" sort="Oualha, Mehdi" uniqKey="Oualha M" first="Mehdi" last="Oualha">Mehdi Oualha</name><affiliation wicri:level="3"><nlm:affiliation>Paediatric Intensive Care Unit, Necker-Enfants-Malades University Hospital, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Paediatric Intensive Care Unit, Necker-Enfants-Malades University Hospital, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Amoura, Zahir" sort="Amoura, Zahir" uniqKey="Amoura Z" first="Zahir" last="Amoura">Zahir Amoura</name><affiliation wicri:level="3"><nlm:affiliation>Inserm UMR-S 1135, Sorbonne Université, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm UMR-S 1135, Sorbonne Université, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Immunology and Infectious disease (CIMI-Paris), Pitié-Salpêtrière Hospital, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Immunology and Infectious disease (CIMI-Paris), Pitié-Salpêtrière Hospital, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Haroche, Julien" sort="Haroche, Julien" uniqKey="Haroche J" first="Julien" last="Haroche">Julien Haroche</name><affiliation wicri:level="3"><nlm:affiliation>Inserm UMR-S 1135, Sorbonne Université, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm UMR-S 1135, Sorbonne Université, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Immunology and Infectious disease (CIMI-Paris), Pitié-Salpêtrière Hospital, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Immunology and Infectious disease (CIMI-Paris), Pitié-Salpêtrière Hospital, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Chommeloux, Juliette" sort="Chommeloux, Juliette" uniqKey="Chommeloux J" first="Juliette" last="Chommeloux">Juliette Chommeloux</name><affiliation wicri:level="3"><nlm:affiliation>Medical Intensive Care Unit, Institut de Cardiologie, AP-HP, Sorbonne University, Pitié-Salpêtrière Hospital, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Medical Intensive Care Unit, Institut de Cardiologie, AP-HP, Sorbonne University, Pitié-Salpêtrière Hospital, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bajolle, Fanny" sort="Bajolle, Fanny" uniqKey="Bajolle F" first="Fanny" last="Bajolle">Fanny Bajolle</name><affiliation wicri:level="3"><nlm:affiliation>Cardiopaediatric Unit, M3-C, Necker-Enfants-Malades University Hospital, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Cardiopaediatric Unit, M3-C, Necker-Enfants-Malades University Hospital, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Beyler, Constance" sort="Beyler, Constance" uniqKey="Beyler C" first="Constance" last="Beyler">Constance Beyler</name><affiliation wicri:level="3"><nlm:affiliation>Cardiopaediatric Unit, Robert Debré University Hospital, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Cardiopaediatric Unit, Robert Debré University Hospital, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bonacorsi, Stephane" sort="Bonacorsi, Stephane" uniqKey="Bonacorsi S" first="Stéphane" last="Bonacorsi">Stéphane Bonacorsi</name><affiliation wicri:level="3"><nlm:affiliation>Department of Microbiology, Robert Debré University Hospital,AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Microbiology, Robert Debré University Hospital,AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Infection-Antimicrobials-Modelling-Evolution IAME, INSERM, UMR-1137, Université de Paris, 75018, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Infection-Antimicrobials-Modelling-Evolution IAME, INSERM, UMR-1137, Université de Paris, 75018, Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Carcelain, Guislaine" sort="Carcelain, Guislaine" uniqKey="Carcelain G" first="Guislaine" last="Carcelain">Guislaine Carcelain</name><affiliation wicri:level="3"><nlm:affiliation>Department of Immunology, Robert Debré University Hospital, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Immunology, Robert Debré University Hospital, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Kone Paut, Isabelle" sort="Kone Paut, Isabelle" uniqKey="Kone Paut I" first="Isabelle" last="Koné-Paut">Isabelle Koné-Paut</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatric Rheumatology Reference centre for Autoinflammatory diseases and amyloidosis (CEREMAIA), Hôpital Bicêtre, AP-HP, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Pediatric Rheumatology Reference centre for Autoinflammatory diseases and amyloidosis (CEREMAIA), Hôpital Bicêtre, AP-HP, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:affiliation>Université Paris Sud-Saclay, UVSQ, 94276 Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Sud-Saclay, UVSQ, 94276 Le Kremlin-Bicêtre</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Le Kremlin-Bicêtre</settlement></placeName></affiliation></author><author><name sortKey="Bader Meunier, Brigitte" sort="Bader Meunier, Brigitte" uniqKey="Bader Meunier B" first="Brigitte" last="Bader-Meunier">Brigitte Bader-Meunier</name><affiliation wicri:level="3"><nlm:affiliation>Paediatric Hematology-Immunology and Rheumatology Department, Reference centre for Rheumatic, AutoImmune and Systemic diseases in children (RAISE), Paris, France, Necker-Enfants-Malades University Hospital, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Paediatric Hematology-Immunology and Rheumatology Department, Reference centre for Rheumatic, AutoImmune and Systemic diseases in children (RAISE), Paris, France, Necker-Enfants-Malades University Hospital, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Laboratory of Immunogenetics of paediatric autoimmune diseases, INSERM UMR 1163, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratory of Immunogenetics of paediatric autoimmune diseases, INSERM UMR 1163, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Faye, Albert" sort="Faye, Albert" uniqKey="Faye A" first="Albert" last="Faye">Albert Faye</name><affiliation wicri:level="3"><nlm:affiliation>General Paediatrics, Department of Infectious Disease and Internal Medicine, Reference centre for Rheumatic, AutoImmune and Systemic diseases in children (RAISE), Paris, France, Robert Debré University Hospital, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>General Paediatrics, Department of Infectious Disease and Internal Medicine, Reference centre for Rheumatic, AutoImmune and Systemic diseases in children (RAISE), Paris, France, Robert Debré University Hospital, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Université de Paris, UFR de Médecine Paris Nord, 75010 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Paris, UFR de Médecine Paris Nord, 75010 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>INSERM UMR 1123, ECEVE, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR 1123, ECEVE, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Meinzer, Ulrich" sort="Meinzer, Ulrich" uniqKey="Meinzer U" first="Ulrich" last="Meinzer">Ulrich Meinzer</name><affiliation wicri:level="3"><nlm:affiliation>General Paediatrics, Department of Infectious Disease and Internal Medicine, Reference centre for Rheumatic, AutoImmune and Systemic diseases in children (RAISE), Paris, France, Robert Debré University Hospital, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>General Paediatrics, Department of Infectious Disease and Internal Medicine, Reference centre for Rheumatic, AutoImmune and Systemic diseases in children (RAISE), Paris, France, Robert Debré University Hospital, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Université de Paris, UFR de Médecine Paris Nord, 75010 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Paris, UFR de Médecine Paris Nord, 75010 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Center for Research on Inflammation, INSERM, UMR1149, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Center for Research on Inflammation, INSERM, UMR1149, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Biology and Genetics of Bacterial Cell Wall Unit, Pasteur Institute, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Biology and Genetics of Bacterial Cell Wall Unit, Pasteur Institute, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Galeotti, Caroline" sort="Galeotti, Caroline" uniqKey="Galeotti C" first="Caroline" last="Galeotti">Caroline Galeotti</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatric Rheumatology Reference centre for Autoinflammatory diseases and amyloidosis (CEREMAIA), Hôpital Bicêtre, AP-HP, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Pediatric Rheumatology Reference centre for Autoinflammatory diseases and amyloidosis (CEREMAIA), Hôpital Bicêtre, AP-HP, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Melki, Isabelle" sort="Melki, Isabelle" uniqKey="Melki I" first="Isabelle" last="Melki">Isabelle Melki</name><affiliation wicri:level="3"><nlm:affiliation>General Paediatrics, Department of Infectious Disease and Internal Medicine, Reference centre for Rheumatic, AutoImmune and Systemic diseases in children (RAISE), Paris, France, Robert Debré University Hospital, AP-HP, Paris, France isabelle.melki@aphp.fr.</nlm:affiliation><country wicri:rule="url">France</country><wicri:regionArea>General Paediatrics, Department of Infectious Disease and Internal Medicine, Reference centre for Rheumatic, AutoImmune and Systemic diseases in children (RAISE), Paris, France, Robert Debré University Hospital, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Paediatric Hematology-Immunology and Rheumatology Department, Reference centre for Rheumatic, AutoImmune and Systemic diseases in children (RAISE), Paris, France, Necker-Enfants-Malades University Hospital, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Paediatric Hematology-Immunology and Rheumatology Department, Reference centre for Rheumatic, AutoImmune and Systemic diseases in children (RAISE), Paris, France, Necker-Enfants-Malades University Hospital, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Laboratory of Neurogenetics and Neuroinflammation, Imagine Institute, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratory of Neurogenetics and Neuroinflammation, Imagine Institute, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j">Annals of the rheumatic diseases</title><idno type="eISSN">1468-2060</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term><term>Betacoronavirus (MeSH)</term><term>Child (MeSH)</term><term>Child, Preschool (MeSH)</term><term>Cohort Studies (MeSH)</term><term>Coronavirus Infections (diagnosis)</term><term>Coronavirus Infections (epidemiology)</term><term>Coronavirus Infections (virology)</term><term>Diagnosis, Differential (MeSH)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Mucocutaneous Lymph Node Syndrome (diagnosis)</term><term>Mucocutaneous Lymph Node Syndrome (virology)</term><term>Pandemics (MeSH)</term><term>Paris (epidemiology)</term><term>Pneumonia, Viral (diagnosis)</term><term>Pneumonia, Viral (epidemiology)</term><term>Pneumonia, Viral (virology)</term><term>Systemic Inflammatory Response Syndrome (diagnosis)</term><term>Systemic Inflammatory Response Syndrome (epidemiology)</term><term>Systemic Inflammatory Response Syndrome (virology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent (MeSH)</term><term>Betacoronavirus (MeSH)</term><term>Diagnostic différentiel (MeSH)</term><term>Enfant (MeSH)</term><term>Enfant d'âge préscolaire (MeSH)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Infections à coronavirus (diagnostic)</term><term>Infections à coronavirus (virologie)</term><term>Infections à coronavirus (épidémiologie)</term><term>Maladie de Kawasaki (diagnostic)</term><term>Maladie de Kawasaki (virologie)</term><term>Mâle (MeSH)</term><term>Pandémies (MeSH)</term><term>Paris (épidémiologie)</term><term>Pneumopathie virale (diagnostic)</term><term>Pneumopathie virale (virologie)</term><term>Pneumopathie virale (épidémiologie)</term><term>Syndrome de réponse inflammatoire généralisée (diagnostic)</term><term>Syndrome de réponse inflammatoire généralisée (virologie)</term><term>Syndrome de réponse inflammatoire généralisée (épidémiologie)</term><term>Études de cohortes (MeSH)</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Paris</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term><term>Mucocutaneous Lymph Node Syndrome</term><term>Pneumonia, Viral</term><term>Systemic Inflammatory Response Syndrome</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Infections à coronavirus</term><term>Maladie de Kawasaki</term><term>Pneumopathie virale</term><term>Syndrome de réponse inflammatoire généralisée</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term><term>Systemic Inflammatory Response Syndrome</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Maladie de Kawasaki</term><term>Pneumopathie virale</term><term>Syndrome de réponse inflammatoire généralisée</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Mucocutaneous Lymph Node Syndrome</term><term>Pneumonia, Viral</term><term>Systemic Inflammatory Response Syndrome</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Paris</term><term>Pneumopathie virale</term><term>Syndrome de réponse inflammatoire généralisée</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Betacoronavirus</term><term>Child</term><term>Child, Preschool</term><term>Cohort Studies</term><term>Diagnosis, Differential</term><term>Female</term><term>Humans</term><term>Male</term><term>Pandemics</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Betacoronavirus</term><term>Diagnostic différentiel</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Pandémies</term><term>Études de cohortes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Current data suggest that COVID-19 is less frequent in children, with a milder course. However, over the past weeks, an increase in the number of children presenting to hospitals in the greater Paris region with a phenotype resembling Kawasaki disease (KD) has led to an alert by the French national health authorities.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Multicentre compilation of patients with KD in Paris region since April 2020, associated with the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ('Kawa-COVID-19'). A historical cohort of 'classical' KD served as a comparator.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Sixteen patients were included (sex ratio=1, median age 10 years IQR (4·7 to 12.5)). SARS-CoV-2 was detected in 12 cases (69%), while a further three cases had documented recent contact with a quantitative PCR-positive individual (19%). Cardiac involvement included myocarditis in 44% (n=7). Factors prognostic for the development of severe disease (ie, requiring intensive care, n=7) were age over 5 years and ferritinaemia >1400 µg/L. Only five patients (31%) were successfully treated with a single intravenous immunoglobulin (IVIg) infusion, while 10 patients (62%) required a second line of treatment. The Kawa-COVID-19 cohort differed from a comparator group of 'classical' KD by older age at onset 10 vs 2 years (p<0.0001), lower platelet count (188 vs 383 G/L (p<0.0001)), a higher rate of myocarditis 7/16 vs 3/220 (p=0.0001) and resistance to first IVIg treatment 10/16 vs 45/220 (p=0.004).</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>Kawa-COVID-19 likely represents a new systemic inflammatory syndrome temporally associated with SARS-CoV-2 infection in children. Further prospective international studies are necessary to confirm these findings and better understand the pathophysiology of Kawa-COVID-19. </p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32527868</PMID><DateCompleted><Year>2020</Year><Month>07</Month><Day>22</Day></DateCompleted><DateRevised><Year>2020</Year><Month>08</Month><Day>14</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1468-2060</ISSN><JournalIssue CitedMedium="Internet"><Volume>79</Volume><Issue>8</Issue><PubDate><Year>2020</Year><Month>08</Month></PubDate></JournalIssue><Title>Annals of the rheumatic diseases</Title><ISOAbbreviation>Ann. Rheum. Dis.</ISOAbbreviation></Journal><ArticleTitle>Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 mimicking Kawasaki disease (Kawa-COVID-19): a multicentre cohort.</ArticleTitle><Pagination><MedlinePgn>999-1006</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1136/annrheumdis-2020-217960</ELocationID><Abstract><AbstractText Label="BACKGROUND">Current data suggest that COVID-19 is less frequent in children, with a milder course. However, over the past weeks, an increase in the number of children presenting to hospitals in the greater Paris region with a phenotype resembling Kawasaki disease (KD) has led to an alert by the French national health authorities.</AbstractText><AbstractText Label="METHODS">Multicentre compilation of patients with KD in Paris region since April 2020, associated with the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ('Kawa-COVID-19'). A historical cohort of 'classical' KD served as a comparator.</AbstractText><AbstractText Label="RESULTS">Sixteen patients were included (sex ratio=1, median age 10 years IQR (4·7 to 12.5)). SARS-CoV-2 was detected in 12 cases (69%), while a further three cases had documented recent contact with a quantitative PCR-positive individual (19%). Cardiac involvement included myocarditis in 44% (n=7). Factors prognostic for the development of severe disease (ie, requiring intensive care, n=7) were age over 5 years and ferritinaemia >1400 µg/L. Only five patients (31%) were successfully treated with a single intravenous immunoglobulin (IVIg) infusion, while 10 patients (62%) required a second line of treatment. The Kawa-COVID-19 cohort differed from a comparator group of 'classical' KD by older age at onset 10 vs 2 years (p<0.0001), lower platelet count (188 vs 383 G/L (p<0.0001)), a higher rate of myocarditis 7/16 vs 3/220 (p=0.0001) and resistance to first IVIg treatment 10/16 vs 45/220 (p=0.004).</AbstractText><AbstractText Label="CONCLUSION">Kawa-COVID-19 likely represents a new systemic inflammatory syndrome temporally associated with SARS-CoV-2 infection in children. Further prospective international studies are necessary to confirm these findings and better understand the pathophysiology of Kawa-COVID-19. <b>Trial registration number</b> NCT02377245.</AbstractText><CopyrightInformation>© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pouletty</LastName><ForeName>Marie</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>General Paediatrics, Department of Infectious Disease and Internal Medicine, Reference centre for Rheumatic, AutoImmune and Systemic diseases in children (RAISE), Paris, France, Robert Debré University Hospital, AP-HP, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Université de Paris, UFR de Médecine Paris Nord, 75010 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Borocco</LastName><ForeName>Charlotte</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Pediatric Rheumatology Reference centre for Autoinflammatory diseases and amyloidosis (CEREMAIA), Hôpital Bicêtre, AP-HP, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Université Paris Sud-Saclay, UVSQ, 94276 Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ouldali</LastName><ForeName>Naim</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>General Paediatrics, Department of Infectious Disease and Internal Medicine, Reference centre for Rheumatic, AutoImmune and Systemic diseases in children (RAISE), Paris, France, Robert Debré University Hospital, AP-HP, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>INSERM UMR 1123, ECEVE, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Caseris</LastName><ForeName>Marion</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>General Paediatrics, Department of Infectious Disease and Internal Medicine, Reference centre for Rheumatic, AutoImmune and Systemic diseases in children (RAISE), Paris, France, Robert Debré University Hospital, AP-HP, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Microbiology, Robert Debré University Hospital,AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Basmaci</LastName><ForeName>Romain</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Departments of General Paediatrics and Paediatric Emergency, Louis-Mourier Hospital, AP-HP, Colombes, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Infection-Antimicrobials-Modelling-Evolution IAME, INSERM, UMR-1137, Université de Paris, 75018, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lachaume</LastName><ForeName>Noémie</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Departments of General Paediatrics and Paediatric Emergency, Louis-Mourier Hospital, AP-HP, Colombes, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Infection-Antimicrobials-Modelling-Evolution IAME, INSERM, UMR-1137, Université de Paris, 75018, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bensaid</LastName><ForeName>Philippe</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of General Paediatrics, Victor Dupouy Hospital, Argenteuil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pichard</LastName><ForeName>Samia</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of General Paediatrics, Victor Dupouy Hospital, Argenteuil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kouider</LastName><ForeName>Hanane</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of General Paediatrics, René Dubos, Pontoise Hospital, Pontoise, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morelle</LastName><ForeName>Guillaume</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of General Paediatrics, Hôpital Bicêtre, AP-HP, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Craiu</LastName><ForeName>Irina</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Paediatric emergency Department, Hôpital Bicêtre, AP-HP, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pondarre</LastName><ForeName>Corinne</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Sickle cell disease referal center, INSERM U955, Centre hospitalier Intercommunal de Créteil, Paris XII University, Créteil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deho</LastName><ForeName>Anna</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Paediatric Intensive Care Unit, Robert Debré University Hospital, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maroni</LastName><ForeName>Arielle</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Paediatric Intensive Care Unit, Robert Debré University Hospital, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Oualha</LastName><ForeName>Mehdi</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Paediatric Intensive Care Unit, Necker-Enfants-Malades University Hospital, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Amoura</LastName><ForeName>Zahir</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Inserm UMR-S 1135, Sorbonne Université, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Immunology and Infectious disease (CIMI-Paris), Pitié-Salpêtrière Hospital, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Haroche</LastName><ForeName>Julien</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Inserm UMR-S 1135, Sorbonne Université, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Immunology and Infectious disease (CIMI-Paris), Pitié-Salpêtrière Hospital, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chommeloux</LastName><ForeName>Juliette</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Medical Intensive Care Unit, Institut de Cardiologie, AP-HP, Sorbonne University, Pitié-Salpêtrière Hospital, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bajolle</LastName><ForeName>Fanny</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Cardiopaediatric Unit, M3-C, Necker-Enfants-Malades University Hospital, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beyler</LastName><ForeName>Constance</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Cardiopaediatric Unit, Robert Debré University Hospital, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bonacorsi</LastName><ForeName>Stéphane</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Microbiology, Robert Debré University Hospital,AP-HP, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Infection-Antimicrobials-Modelling-Evolution IAME, INSERM, UMR-1137, Université de Paris, 75018, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carcelain</LastName><ForeName>Guislaine</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Immunology, Robert Debré University Hospital, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Koné-Paut</LastName><ForeName>Isabelle</ForeName><Initials>I</Initials><Identifier Source="ORCID">0000-0001-8939-5763</Identifier><AffiliationInfo><Affiliation>Department of Pediatric Rheumatology Reference centre for Autoinflammatory diseases and amyloidosis (CEREMAIA), Hôpital Bicêtre, AP-HP, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Université Paris Sud-Saclay, UVSQ, 94276 Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bader-Meunier</LastName><ForeName>Brigitte</ForeName><Initials>B</Initials><Identifier Source="ORCID">0000-0001-8476-8196</Identifier><AffiliationInfo><Affiliation>Paediatric Hematology-Immunology and Rheumatology Department, Reference centre for Rheumatic, AutoImmune and Systemic diseases in children (RAISE), Paris, France, Necker-Enfants-Malades University Hospital, AP-HP, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Laboratory of Immunogenetics of paediatric autoimmune diseases, INSERM UMR 1163, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Faye</LastName><ForeName>Albert</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>General Paediatrics, Department of Infectious Disease and Internal Medicine, Reference centre for Rheumatic, AutoImmune and Systemic diseases in children (RAISE), Paris, France, Robert Debré University Hospital, AP-HP, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Université de Paris, UFR de Médecine Paris Nord, 75010 Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>INSERM UMR 1123, ECEVE, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meinzer</LastName><ForeName>Ulrich</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>General Paediatrics, Department of Infectious Disease and Internal Medicine, Reference centre for Rheumatic, AutoImmune and Systemic diseases in children (RAISE), Paris, France, Robert Debré University Hospital, AP-HP, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Université de Paris, UFR de Médecine Paris Nord, 75010 Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Center for Research on Inflammation, INSERM, UMR1149, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Biology and Genetics of Bacterial Cell Wall Unit, Pasteur Institute, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Galeotti</LastName><ForeName>Caroline</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Pediatric Rheumatology Reference centre for Autoinflammatory diseases and amyloidosis (CEREMAIA), Hôpital Bicêtre, AP-HP, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Melki</LastName><ForeName>Isabelle</ForeName><Initials>I</Initials><Identifier Source="ORCID">0000-0002-8057-333X</Identifier><AffiliationInfo><Affiliation>General Paediatrics, Department of Infectious Disease and Internal Medicine, Reference centre for Rheumatic, AutoImmune and Systemic diseases in children (RAISE), Paris, France, Robert Debré University Hospital, AP-HP, Paris, France isabelle.melki@aphp.fr.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Paediatric Hematology-Immunology and Rheumatology Department, Reference centre for Rheumatic, AutoImmune and Systemic diseases in children (RAISE), Paris, France, Necker-Enfants-Malades University Hospital, AP-HP, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Laboratory of Neurogenetics and Neuroinflammation, Imagine Institute, Paris, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName><AccessionNumberList><AccessionNumber>NCT02377245</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>06</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Ann Rheum Dis</MedlineTA><NlmUniqueID>0372355</NlmUniqueID><ISSNLinking>0003-4967</ISSNLinking></MedlineJournalInfo><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Disease" UI="C000705967">pediatric multisystem inflammatory disease, COVID-19 related</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Ann Rheum Dis. 2020 Aug;79(8):993-995</RefSource><PMID Version="1">32571869</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="Y">Betacoronavirus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000453" 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care</Keyword></KeywordList><CoiStatement>Competing interests: None declared.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>05</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>05</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>06</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>6</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>7</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>6</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32527868</ArticleId><ArticleId IdType="pii">annrheumdis-2020-217960</ArticleId><ArticleId 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name="Île-de-France"><name sortKey="Pouletty, Marie" sort="Pouletty, Marie" uniqKey="Pouletty M" first="Marie" last="Pouletty">Marie Pouletty</name></region><name sortKey="Amoura, Zahir" sort="Amoura, Zahir" uniqKey="Amoura Z" first="Zahir" last="Amoura">Zahir Amoura</name><name sortKey="Amoura, Zahir" sort="Amoura, Zahir" uniqKey="Amoura Z" first="Zahir" last="Amoura">Zahir Amoura</name><name sortKey="Bader Meunier, Brigitte" sort="Bader Meunier, Brigitte" uniqKey="Bader Meunier B" first="Brigitte" last="Bader-Meunier">Brigitte Bader-Meunier</name><name sortKey="Bader Meunier, Brigitte" sort="Bader Meunier, Brigitte" uniqKey="Bader Meunier B" first="Brigitte" last="Bader-Meunier">Brigitte Bader-Meunier</name><name sortKey="Bajolle, Fanny" sort="Bajolle, Fanny" uniqKey="Bajolle F" first="Fanny" last="Bajolle">Fanny Bajolle</name><name sortKey="Basmaci, Romain" sort="Basmaci, Romain" uniqKey="Basmaci R" first="Romain" last="Basmaci">Romain Basmaci</name><name sortKey="Basmaci, Romain" 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uniqKey="Carcelain G" first="Guislaine" last="Carcelain">Guislaine Carcelain</name><name sortKey="Caseris, Marion" sort="Caseris, Marion" uniqKey="Caseris M" first="Marion" last="Caseris">Marion Caseris</name><name sortKey="Caseris, Marion" sort="Caseris, Marion" uniqKey="Caseris M" first="Marion" last="Caseris">Marion Caseris</name><name sortKey="Chommeloux, Juliette" sort="Chommeloux, Juliette" uniqKey="Chommeloux J" first="Juliette" last="Chommeloux">Juliette Chommeloux</name><name sortKey="Craiu, Irina" sort="Craiu, Irina" uniqKey="Craiu I" first="Irina" last="Craiu">Irina Craiu</name><name sortKey="Deho, Anna" sort="Deho, Anna" uniqKey="Deho A" first="Anna" last="Deho">Anna Deho</name><name sortKey="Faye, Albert" sort="Faye, Albert" uniqKey="Faye A" first="Albert" last="Faye">Albert Faye</name><name sortKey="Faye, Albert" sort="Faye, Albert" uniqKey="Faye A" first="Albert" last="Faye">Albert Faye</name><name sortKey="Faye, Albert" sort="Faye, Albert" uniqKey="Faye A" 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sortKey="Lachaume, Noemie" sort="Lachaume, Noemie" uniqKey="Lachaume N" first="Noémie" last="Lachaume">Noémie Lachaume</name><name sortKey="Maroni, Arielle" sort="Maroni, Arielle" uniqKey="Maroni A" first="Arielle" last="Maroni">Arielle Maroni</name><name sortKey="Meinzer, Ulrich" sort="Meinzer, Ulrich" uniqKey="Meinzer U" first="Ulrich" last="Meinzer">Ulrich Meinzer</name><name sortKey="Meinzer, Ulrich" sort="Meinzer, Ulrich" uniqKey="Meinzer U" first="Ulrich" last="Meinzer">Ulrich Meinzer</name><name sortKey="Meinzer, Ulrich" sort="Meinzer, Ulrich" uniqKey="Meinzer U" first="Ulrich" last="Meinzer">Ulrich Meinzer</name><name sortKey="Meinzer, Ulrich" sort="Meinzer, Ulrich" uniqKey="Meinzer U" first="Ulrich" last="Meinzer">Ulrich Meinzer</name><name sortKey="Melki, Isabelle" sort="Melki, Isabelle" uniqKey="Melki I" first="Isabelle" last="Melki">Isabelle Melki</name><name sortKey="Melki, Isabelle" sort="Melki, Isabelle" uniqKey="Melki I" first="Isabelle" last="Melki">Isabelle Melki</name><name sortKey="Melki, Isabelle" sort="Melki, Isabelle" uniqKey="Melki I" first="Isabelle" last="Melki">Isabelle Melki</name><name sortKey="Morelle, Guillaume" sort="Morelle, Guillaume" uniqKey="Morelle G" first="Guillaume" last="Morelle">Guillaume Morelle</name><name sortKey="Oualha, Mehdi" sort="Oualha, Mehdi" uniqKey="Oualha M" first="Mehdi" last="Oualha">Mehdi Oualha</name><name sortKey="Ouldali, Naim" sort="Ouldali, Naim" uniqKey="Ouldali N" first="Naim" last="Ouldali">Naim Ouldali</name><name sortKey="Ouldali, Naim" sort="Ouldali, Naim" uniqKey="Ouldali N" first="Naim" last="Ouldali">Naim Ouldali</name><name sortKey="Pichard, Samia" sort="Pichard, Samia" uniqKey="Pichard S" first="Samia" last="Pichard">Samia Pichard</name><name sortKey="Pondarre, Corinne" sort="Pondarre, Corinne" uniqKey="Pondarre C" first="Corinne" last="Pondarre">Corinne Pondarre</name><name sortKey="Pouletty, Marie" sort="Pouletty, Marie" uniqKey="Pouletty M" first="Marie" last="Pouletty">Marie Pouletty</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 mimicking Kawasaki disease (Kawa-COVID-19): a multicentre cohort.
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HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:32527868" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a CovidFranceV1
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